GAVI's role in the market requires it to be a big enough player to provide certainty to countries and manufacturers in an otherwise uncertain funding environment.

Three kinds of uncertainty have caused millions of children to go without vaccines:

• The uncertainty of country demand (or ability to pay) for vaccines
• Uncertainties related to vaccine research and development on the part of manufacturers
• The lack of predictability in funding.

The GAVI Alliance mediates between these uncertainties and our desired goals to:

• Accelerate product development and introduction
• Improve incentives for country uptake and co-payment
• Realize efficiencies in vaccine pricing

This means GAVI must have access to cash or to firm long-term funding commitments.

GAVI and its donor partners address the market forces influencing pharmaceutical companies' decisions to invest in the development of vaccines needed in poor regions. These vaccines would not otherwise come to market or their introduction would be delayed by years or even decades.

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